Table 1

Interdisciplinary treatment concept for patients with Apert syndrome at the University Hospital of Münster (individual adaptions allowed).

Stage
Age
Procedure

1
3–6 months
Eradicative-osteoclastic method [35]

2
7–10 years
LeFort III osteotomy +
Frontal advancement +
Protraction face mask immediately postoperatively for 6–12 months (rapid stenosis, problems with anchorage of the orthodontic appliance due to exfoliation of deciduous teeth, and eruption of permanent teeth)
Early LeFort III osteotomy might help to avoid a (second) LeFort III osteotomy at stage 5, and thus reduce surgical risks.

3
> 9 years
Extraction therapy

4
> 10 years
Orthodontic treatment (preparation for orthognathic surgery), retention

5
> 16 years
Orthognathic surgery

Hohoff et al. Head & Face Medicine 2007 3:10   doi:10.1186/1746-160X-3-10

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