Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma
1 Department of Oral and Maxillofacial Surgery, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany
2 Department of Oral and Maxillofacial Plastic Surgery, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany
3 Department of Maxillofacial Surgery, University Medical Center Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany
4 Department of Pathology, University of Jena, Ziegelmühlenweg 1, 07740, Jena, Germany
5 Department of Maxillofacial Surgery, University of Münster, Waldeyerstraße 30, 48149, Münster, Germany
6 Institute of Pathology, HELIOS Hospital Erfurt, Nordhäuser Strasse 74, 99089, Erfurt, Germany
Head & Face Medicine 2008, 4:17 doi:10.1186/1746-160X-4-17Published: 31 July 2008
acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction.
Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, γ2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, β-catenin, E-cadherin, α-smooth-muscle-actin and Fli-1 were done.
Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and β-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities.
Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.