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Bovine pericardium based non-cross linked collagen matrix for successful root coverage, a clinical study in human

Markus Schlee1*, Shahram Ghanaati23, Ines Willershausen4, Michael Stimmlmayr5, Anton Sculean6 and Robert A Sader2

Author Affiliations

1 Private Practice. Bayreuther Strasse 39, 91301 Forchheim, Germany

2 Department of Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Germany

3 Institute of Pathology, Johannes Gutenberg Universität Mainz, Germay

4 Department of Operative Dentistry, University Medical Centre of the Johannes Gutenberg University Mainz, Germany

5 Private Practice, Josef-Heiligenbrunner-Str.2, 93413 Cham

6 Department of Periodontology, University of Bern, Bern, Switzerland

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Head & Face Medicine 2012, 8:6  doi:10.1186/1746-160X-8-6

Published: 5 March 2012



The aim of this study was to clinically assess the capacity of a novel bovine pericardium based, non-cross linked collagen matrix in root coverage.


62 gingival recessions of Miller class I or II were treated. The matrix was adapted underneath a coronal repositioned split thickness flap. Clinical values were assessed at baseline and after six months.


The mean recession in each patient was 2.2 mm at baseline. 6 Months after surgery 86.7% of the exposed root surfaces were covered. On average 0,3 mm of recession remained. The clinical attachment level changed from 3.5 ± 1.3 mm to 1,8 ( ± 0,7) mm during the observational time period. No statistically significant difference was found in the difference of probing depth. An increase in the width of gingiva was significant. With a baseline value of 1.5 ± 0.9 mm an improvement of 2.4 ± 0.8 mm after six month could be observed. 40 out of 62 recessions were considered a thin biotype at baseline. After 6 months all 62 sites were assessed thick.


The results demonstrate the capacity of the bovine pericardium based non-cross linked collagen matrix for successful root coverage. This material was able to enhance gingival thickness and the width of keratinized gingiva. The percentage of root coverage achieved thereby is comparable to existing techniques. This method might contribute to an increase of patient's comfort and an enhanced aesthetical outcome.

Gingival recession; root coverage; collagen matrix; guided tissue regeneration; bovine pericardium; connective tissue