Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma.
Driemel O, Müller-Richter UD, Hakim SG, Bauer R, Berndt A, Kleinheinz J, Reichert TE, Kosmehl H.
Department of Oral and Maxillofacial Plastic Surgery, University of Würzburg, Würzburg, Germany. oliver.driemel@klinik.uni-regensburg.de
BACKGROUND: acantholytic squamous cell carcinomas (ASCC) and intraoral angiosarcoma share similar histopathological features. Aim of this study was to find marker for a clear distinction. METHODS: Four oral acantholytic squamous cell carcinomas and one intraoral angiosarcoma are used to compare the eruptive intraoral growth-pattern, age-peak, unfavourable prognosis and slit-like intratumorous spaces in common histological staining as identical clinical and histopathological features. Immunohistochemical staining for pancytokeratin, cytokeratin, collagen type IV, gamma2-chain of laminin-5, endothelial differentiation marker CD31 and CD34, F VIII-associated antigen, Ki 67-antigen, beta-catenin, E-cadherin, alpha-smooth-muscle-actin and Fli-1 were done. RESULTS: Cytokeratin-immunoreactive cells can be identified in both lesions. The large vascularization of ASCC complicates the interpretation of vascular differential markers being characteristic for angiosarcoma. Loss of cell-cell-adhesion, monitored by loss of E-cadherin and beta-catenin membrane-staining, are indetified as reasons for massive expression of invasion-factor ln-5 in ASCC and considered responsible for unfavourable prognosis of ASCC. Expression of Fli-1 in angiosarcoma and cellular immunoreaction for ln-5 in ASCC are worked out as distinguishing features of both entities. CONCLUSION: Fli-1 in angiosarcoma and ln-5 in ASCC are distinguishing features.
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PMID: 18671846 [PubMed - indexed for MEDLINE]PMCID: PMC2515303